DOI: 10.36347/sjmcr.2014.v02i06.002

Pages: 360-361

Systemic Mastocytosis, a rare lymphoproliferative disorder that results in spontaneous mast cell degranulation, presents a unique challenge for the Anesthesiologist. We describe a patient with this disease who presented for routine outpatient foot surgery. In the past, the patient had experienced anaphylaxis as well as episodic mast cell mediator release, resulting in significant nausea, vomiting, pruritis, urticaria pigmentosa, and ostealgia. While precise guidelines for premedicating these patients are lacking, we were able to achieve a successful outcome by premedicating the patient with both H1 and H2 blockers, a mast cell stabilizer, and steroids.