DOI: 10.36347/sjmcr.2014.v02i06.009

Pages: 380-383

Pancreatic Neuroendocrine Tumours (PNET) are extremely rare compared to their exocrine counterparts accounting for approximately 1% of all primary pancreatic tumours. They may be functional or non-functional depending upon the secretion of hormones. The diagnostic grading and prognostic criteria for PNET's have been controversial in surgical pathology and clinical medicine. Most PNET's are sporadic however some of them may occur as part of familial tumors (inherited), such as multiple endocrine neoplasms Type 1 (MEN 1 syndrome) , von hippel-lindau syndrome (VHL), neurofibromatosis Type I (nf-I) and tuberous sclerosis. We present a case of 65yr old male who presented with abdominal pain, vomiting and weight loss. CT revealed a mass in the uncinate process of pancreas. Pancreaticoduodenectomy was performed with a clinical diagnosis of pancreatic neoplasm. Histopathological diagnosis of PNET was made. The PNET presents usually with non specific symptoms and has a low incidence, therefore early detection and pathological diagnosis of PNET histologically and immunohistochemically helps in management of the case and may prevent metastasis.