DOI: 10.36347/sjmcr.2014.v02i07.004

Pages: 438-440

Primary urothelial carcinoma (UC) of the prostate is rare and accounts for only 0.7-2.8% of all prostate cancers. Unlike conventional adenocarcinoma of the prostate, UC does not express prostate-specific antigen (PSA) which can make diagnosis challenging due to both unexpected serum PSA levels and immunohistochemical profiles. We report the case of a 66 year-old man who was eventually diagnosed with primary urothelial carcinoma of the prostate after he presented with lower urinary tract symptoms (LUTS) in the context of an undetectable serum PSA level. This case highlights the potential pitfall of overlooking the significance of an undetectable PSA level and details the manner in which this rare variant of prostate malignancy can present.