DOI: 10.36347/sjmcr.2014.v02i08.007

Pages: 523-525

Pyrexia of unknown origin (PUO) is one of the major diagnostic challenges. A 43 year old patient with rheumatic heart disease (RHD) presented with PUO and suspected to have subacute bacterial endocarditis (SBE) was treated only to be later diagnosed with connective tissue disorder Systemic Lupus Erythematosis (SLE) as the cause. Two disease entities occurring with similar presentations pose challenges both diagnostically and therapeutically making it essential for physicians to have a high index of suspicion and initiate treatment.