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Scholars Journal of Medical Case Reports | Volume-2 | Issue-11
Myeloid Sarcoma Masquerading As Lymphoma- A Diagnostic Challenge
Kavitha K.P., Sangeetha K. Nayanar, Chandran K.Nayar, Aswathi Krishnan M
Published: Nov. 29, 2014 |
125
75
DOI: 10.36347/sjmcr.2014.v02i11.009
Pages: 726-728
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Abstract
Myeloid sarcoma (MS) is a rare extra-medullary tumor and its presentation as generalized lymphadenopathy is
still rarer. It can mimic lymphoma clinically radiologically, cytologically and even histologically, presenting as a
diagnostic challenge. This is an unusual case of myeloid sarcoma in a 52 year old man who presented with generalized
lymphadenopathy and then detected to have chronic myeloid leukemia. Clinical, radiological and cytological features
favored a diagnosis of lymphoma. But histopathological evaluation of cervical lymph node, simultaneous bone marrow
trephine biopsy and immunohistochemical work up helped us to exclude lymphoma and confirm the diagnosis of
myeloid sarcoma. BCR/ABL translocation analysis confirmed the diagnosis of associated chronic myeloid leukemia. We
report this case to emphasize the need of appropriate use of ancillary tests like immunohistochemistry and cytogenetic
study. Even though generalized lymphadenopathy is a presentation of lymphoma, it can also be an early manifestation of
MS. The correct timely diagnosis is crucial for proper patient management.