DOI: 10.36347/sjmcr.2014.v02i11.009

Pages: 726-728

Myeloid sarcoma (MS) is a rare extra-medullary tumor and its presentation as generalized lymphadenopathy is still rarer. It can mimic lymphoma clinically radiologically, cytologically and even histologically, presenting as a diagnostic challenge. This is an unusual case of myeloid sarcoma in a 52 year old man who presented with generalized lymphadenopathy and then detected to have chronic myeloid leukemia. Clinical, radiological and cytological features favored a diagnosis of lymphoma. But histopathological evaluation of cervical lymph node, simultaneous bone marrow trephine biopsy and immunohistochemical work up helped us to exclude lymphoma and confirm the diagnosis of myeloid sarcoma. BCR/ABL translocation analysis confirmed the diagnosis of associated chronic myeloid leukemia. We report this case to emphasize the need of appropriate use of ancillary tests like immunohistochemistry and cytogenetic study. Even though generalized lymphadenopathy is a presentation of lymphoma, it can also be an early manifestation of MS. The correct timely diagnosis is crucial for proper patient management.