DOI: 10.36347/sjams.2015.v03i01.013

Pages: 53-57

The remote effect of priapism on haematological indices and liver function is still obscured. We evaluated the reversal effect of vitamin C on remote changes in blood parameters and liver function of Sprague – Dawley rats. 25 male rats were randomly divided into 5 groups of 5 rats each. Group 1 served as the control and was treated with 5ml/kg body weight normal saline. Group 2 rats were induced with priapism. Group 3 was induced with priapism and then treated with 25 mg/kg body weight of vitamin C. Group 4 was induced with priapism and then treated with 2.5mg/kg body weight of testosterone. Group 5 was induced with priapism but were treated with both vitamin C and testosterone. Priapism was induced for one week followed by 6 hours post priapism administration of testosterone and vitamin C. Results showed markedly elevated liver enzymes in treated groups especially in groups 2 and 4. The haematological indices also revealed anaemia and leucopaenia in various treated groups. Although the role of both testosterone and Vitamin C was evaluated, only vitamin C treated groups showed improvement in blood parameters and liver function of Sprague-Dawley rats.