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Scholars Journal of Applied Medical Sciences | Volume-3 | Issue-01
Dermatoglyphics in Type 2 Diabetes with Implications on Gene Linkage or Early Developmental Noise: Past Perspectives, Current Trends, & Future Prospects
Seile Yohannes, Getachew Alebie, Lemessa Assefa
Published: March 30, 2015 |
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107
DOI: 10.36347/sjams.2015.v03i01.060
Pages: 297-305
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Abstract
Clinical Dermatoglyphics is an emerging field of active research with profoung implications, with analysis
techniques following descriptive case-control studies. Such studies assess peculiar & significant manifestations among
affected individuals relative to healthy controls, attributing these outcomes to gene linkage or developmental instability
during prenatal development. This paper critically reviews studies done over a period of 42 years (1972-2014) that have
followed such analysis techniques in T2DM, highlighting on strengths & weaknesses. Low sample sizes, negligence of
the distinct nature of types & subtypes of DM, negligence of the occurrence of common concurrent disorders having their
own impacts on Dermatoglyphics, and a general paucity of studies addressing the relationship between developmental
noise measures (Fluctuating Asymmetry) & T2DM are observable limitations that could be attributable to the
contradictory findings among the published papers, that need be addressed by future researchers. All in all, inferable
positive prdictive values indicative of a predisposition to T2DM have been sumarized, emphasis on the need for further
studies from varied populations with larger sample sizes has been proposed inorder to come to conclusive results.