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Scholars Journal of Applied Medical Sciences | Volume-3 | Issue-01
Correlation of Serum Gamma Glutamyl Transferase with Atherogenic Dyslipidemia in Obese Individuals
P. Josephine Latha, S. Ganesan
Published: March 30, 2015 |
164
128
DOI: 10.36347/sjams.2015.v03i01.077
Pages: 387-391
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Abstract
Obesity is one of the major public health concerns and is a growing epidemic in the present scenario. Recent
studies have shown increased association of the medical complications of obesity with gamma glutamyl
transferase(GGT) levels. Some studies have also found that obese individuals with high normal serum γ-
glutamyltransferase (GGT) activity are associated with the risk of type 2 diabetes. Moreover GGT activity in
atherosclerotic plaques has also been proved recently. In the present study we propose to establish the correlation of
serum GGT levels with atherogenic dyslipidemia in obese individuals. The study included 100 obese subjects and 100
non-obese healthy controls. BMI, waist circumference and blood pressure (BP) were measured as per the standard
guidelines. Lipid profile, Fasting blood sugar and GGT levels were assayed in a fasting venous sample using standard
kits in an autoanalyzer. Statistical analysis was done using SPSS software. In this study atherogenic dyslipidemia in
obese individuals was evident from their TGL, HDL levels and lipid ratios. The fasting blood sugar, total cholesterol,
triglycerides, LDL-C VLDL-C, GGT were significantly increased and HDL-C was decreased in cases compared to
controls (p< 0.001). Serum GGT was significantly positively correlated with TC (r: 0.72, p<0.001), TGL (r: 0.662,
p<0.001), atherogenic lipid ratios TC/HDL (r: 0.817, p<0.001) and TGL/HDL (r: 0.814, p<0.001)) and negatively
correlated with HDL (r: -0.773, p<0.001) in obese individuals (p<0.001). Hence GGT can be considered as an early,
reliable and cost-effective marker of atherosclerosis and visceral fat. Further large population prospective cohort studies
are needed to consider GGT in screening people at risk for developing atherosclerosis.