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Scholars Journal of Applied Medical Sciences | Volume-3 | Issue-01
A rare presentation of Congenital Leukemia in Down’s Syndrome
Jayaraj Patil, Jyothidevi Patil, Shrinivas R Deshapande
Published: March 31, 2015 | 149 116
DOI: 10.36347/sjams.2015.v03i01.098
Pages: 494-497
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Abstract
One day old preterm newborn presented at 10 hours of life with respiratory distress, cyanosis, shock and poor suck. Detailed examination revealed Down’s facies, hepato-splenomegaly and severe pallor suggestive of sepsis. Peripheral blood smear revealed hyperleukocytosis, thrombocytopenia and presence of myeloblasts, also, the bone marrow study revealed an increase in myeloblasts. Other causes of leukemoid reaction were ruled out and a final diagnosis of congenital leukaemia was confirmed by immunophenotyping.