DOI: 10.36347/sjams.2022.v10i10.034

Pages: 1780-1784

Background: The incidence of Leukaemia is increasing in developing countries, particularly in Africa. Cancer-associated inflammation is a significant factor in improvements and survival of people with cancers. This study was aimed at evaluating changes in leucocyte functions and hematological parameters among leukaemia patients in Abuja, Nigeria. Method: The study comprised 30 leukaemia patients attending the Oncology Department of National Hospital Abuja, Nigeria from July 2019 to August 2020 and 20 healthy people. Three millimetres (3m1) of blood was collected from each participant into EDTA bottle and analyzed for full blood and differential counts using the Mythic 22 (Orphne, Switzerland) five-part differential hematology analyzer. CD4 and CD8 T cells were analyzed out by flow cytometry. Data analysis was done using IBM-SPSS Inc., Chicago, IL, USA version-25.0. T-test was used to compare means of between groups and the significant value was set as P<0.05. Result: All hematological parameters were significantly lower (P<0.05) in leukaemia patients as compared to control except for monocytes and basophils. Also, WBC was significantly higher in leukaemia patients (13.0 ±0.57x109/L) as compared to 6.11±1.14109/L in control (P<0.05). CD4 (775.4082.91Cell/u1) and CD8 counts (634.40±101.43Cell/u1) were significantly higher in control as compared to leukaemia patients. Also, CD4/CD8 ratio was significantly higher (P<0.05) among control group 1.24 ± 0.15 than leukaemia patients (1.17 ± 0.09). Conclusion: This study found that changes in hematological parameters and leucocyte functions are significantly associated with leukaemia. The use of therapies that boost immune response in patients with leukemia is recommended.