DOI: 10.36347/sjams.2015.v03i02.097

Pages: 1018-1026

Breast cancer is the most common cancer among women both in developed and developing countries. The current study was conducted to correlate the molecular sub-typing of breast cancer with the Histological typing, Bloom Richardson grading and TNM staging. A cross sectional study was conducted on 70 invasive breast carcinoma samples from November 2012 to October 2014. Cases were sub-classified using immunohistochemical staining for ER, PR, Her- 2/neu, Ki-67, CK 5/6 into following subtypes luminal A, luminal B, Her-2/neu positive, basal-like and normal-like. Most common molecular subtype was Luminal A representing 27.1% of total cases, and least common subtype was normallike comprising 5.7% of total cases. Luminal B, Her-2/ neu positive, Basal-like molecular subtypes belonged to 25.7%, 25.7%, 15.7% cases respectively. The following variables were significantly associated with IHC subtypes: number of lymph node involved, Bloom-Richardson grading and TNM staging with p value < 0.05. Luminal B, Her-2/neu positive and basal-like phenotype are found to be more associated with Large tumor size, high Nottingham modification of Bloom- Richardson Grade and high TNM stage than with luminal A and normal-like phenotype.