DOI: 10.36347/sjmcr.2020.v08i07.005

Pages: 669-672

The clinically reported case of liver involvement with multiple myeloma (MM) is rare. Relatively, most of the reported unusual manifestation of MM has been in autopsied series; since far, the data around diagnosis, clinical feature, treatment, and prognosis of patients are still unknown. We report a case of a 73-year-old patient with MM who is admitted for upper gastrointestinal haemorrhage made of hematemesis of medium abundance with anemic syndrome, hepatomegaly with ascites of average abundance .Elsewhere osteo-articular examination is without abnormality. Initial laboratories included elevated liver function tests (aspartate aminotransferase 3*N U/L and alanine aminotransferase 2*N U/L) and normocytic normochromic anemia nonregenerative (HB to 09.5g/dl, reticulocyte rate to 20000/mm3) with cholestasis (GGT = 7*N, PAL = 5*N, BT = 3*N predominantly direct). A myelogram with karyotype was made having concluded a plasmocyte infiltration at 20% consisting of dystrophic plasma cells.A liver biopsy revealed a diffuse portal and sinusoidal infiltration of plasma cells. In this report, we review the literature of liver involvement in multiple myeloma.