DOI: 10.36347/sjds.2016.v03i09.002

Pages: 247-250

Abstract: The pathogenesis of enamel caries involves an imbalance in the physiological process of
remineralization/ demineralization of the dental
structure.
White-spot lesions are the earliest macroscopic evidence of enamel caries. The subsurface loss will continue if early treatment was not made, and eventually the surface layer will collapse and lead to a cavity formation. Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is a unique, naturally derived protein-based remineralizing mechanism. By its incorporation at this stage, the lesion can be reversed. It will have a strong impact on the public health aspects of caries control. The aim of this review is to describe the chemical nature, mechanism of action, and effectiveness of CPP-ACP as a remineralizing agent and its various uses in clinical conditions as well as the different methods of application of CPP-ACP products in modern practice.