DOI: 10.36347/sjams.2015.v03i05.001

Pages: 1818-1820

Peptic ulcer disease was one of the major causesof morbidity and mortality until the last decades of the 20th century. In resent time epidemiological trends started to point to an impressive fall in its incidence due to. the discovery of effective and potent acid suppressants and antibiotics against Helicobacter pylori. The main aim and objective of this study is to compare between, conservative medical lines of treatment versus surgical approach in treatment of chronic peptic ulcer. The present clinical study was carried out at surgical wards of Subbaiah Institute of Medical Sciences and Research Centre, in the period of March 2014 to March 2015. Patients were selected based on inclusion and exclusion criteria’s. Following selection of patients, they were subjected to medical line of treatment for 2-3 months with Omeprazole 40mg, Amoxicillin 1550mg / Clarithromycin 500mg and Tinidazole 1000 mg (7days course in a month repeated for 2 months) and the cases were followed up for varying length of time. Among 15 cases, 10 cases were treated successfully with medical line of management. One case had anterior duodenal ulcer perforation for which emergency laparotomy and closure of perforation was done and other 4 cases underwent posterior gastrojejunostomy with bilateral truncalvagatomy for peptic ulcer complications like deformed duodenal cap and early signs of pyloric stenosis. The incidence of surgery in recent years for chronic Peptic Ulcer Disease has reduced because of advent of proton pump inhibitors and H2 receptor blockers and combination drugs with antibiotics which proved effective against Helicobacter pylori infection.