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Scholars Journal of Applied Medical Sciences | Volume-3 | Issue-05
Non-Secretors of ABH Antigens Are Susceptible to Falciparum Malaria
Igbeneghu C, Olisekodiaka MJ, Okanlawon BM, Onuegbu JA, Odaibo AB
Published: Aug. 26, 2015 |
170
107
DOI: 10.36347/sjams.2015.v03i05.006
Pages: 1838-1841
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Abstract
ABH secretor status has been associated with a number of infectious diseases. This study was carried out to
determine whether secretion of ABH antigens was associated falciparum infection. A total of 600 individuals (284 males
and 316 females) of age ≥16 years participated in this study after clinical examination and informed consent was
obtained. The participants consisted of three groups. The first group consisted of 200 patients with symptomatic malaria.
The second group consisted of 200 individuals with asymptomatic malaria while the third group (control group)
consisted of 200 apparently healthy individuals without malaria as of the time of investigation. Blood and saliva samples
were taken from each participant for examination of malaria parasite and secretor status respectively. Thick and thin
Giemsa stained blood smear were prepared for malaria parasite examination and identification. Secretor status was
determined among the participants using haemagglutination inhibition technique. The results showed that the proportion
of non-secretors in the symptomatic malaria group (30.5%) was significantly higher than that of non-secretors in the
control group (20.5%) (ᵡ2 = 5.264, df = 1, p = 0.022). The proportion of non-secretors in the asymptomatic malaria group
(26.5%) was not significantly different from that of non-secretors in the control group (20.5%) (ᵡ2 = 2.003, df = 1, p =
0.157). We conclude that Non-secretion of ABH substances is associated with acute falciparium malaria.