DOI: 10.36347/sjams.2015.v03i05.040

Pages: 1992-2000

Breast cancer is the most commonly diagnosed cancer in women worldwide, and is the second leading cause of cancer deaths. Female breast cancer is by far the leading cancer in the Sudan. It accounts for 16.5% of all cancers (30.24% of all female cancers in 2009). Sudan is experiencing rapidly increasing cancer incidences that carry many challenges that are distinctive of developing countries. These include a high incidence of advanced, complicated stage of the disease at presentation, and a high frequency of cancer that is related to a number of risk factors that are required for stabilization. The aim of this study was to find out the association between lipid profile and breast cancer among Sudanese women. This is a retrospective case control study was conducted at Radiation and Isotope Center- Khartoum (Sudan), during the period from January to April 2011. In these study 50 patients (newly diagnosed with breast cancer) their age varied from20 to 80 years with mean age of 48.3 years. There were 50 healthy controls with age group of 20 to 80 years with mean age of 48.6years. Serum Lipid profile was done in these patient’s fasting blood samples. Cholesterol, HDL-cholesterol and Triglycerides were measured manual using Spinreact reagent and LDL cholesterol was calculated using Friedewald formula. Serum cholesterol and LDL cholesterol were significantly elevated in patients with breast cancer when compared with controls (p<0.0001 and p<0.0001respectively).Whereas the levels of HDL cholesterol and triglycerides did not show any significant changes between the patients and the controls. (p= 0.0637and 0.05548 respectively). This study concludes that, there is a significant association between elevation of serum total cholesterol and LDL-cholesterol and risk of breast cancer in Sudanese women. A cohort study is highly recommended to document this relationship.