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Scholars Journal of Applied Medical Sciences | Volume-3 | Issue-05
Estimation of total and ionized magnesium and its correlation with the glycated hemoglobin in newly diagnosed subjects of type 2 Diabetes Mellitus
Madaan H, Agarwal P, Reddy VS, Garg R, Gupta K, Panjeta P, Kulshreshtha M
Published: Aug. 30, 2015 |
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106
DOI: 10.36347/sjams.2015.v03i05.061
Pages: 2100-2105
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Abstract
Mg deficiency underlies the mechanism of insulin resistance of conditions associated with altered glucose
tolerance, such as t2DM. Despite of many reports showing deranged magnesium level in t2DM, most of these studies
have focused on level of t Mg in spite of the fact that iMg is the physiological form. Furthermore, data on iMg in newly
diagnosed t2DM yet to start treatment is scarce. Therefore, this study was undertaken to evaluate both tMg and iMg level
in newly diagnosed type 2 diabetes mellitus. This study was conducted to evaluate serum levels of tMg and iMg in 30
patients with newly diagnosed t2DM and 30 non-diabetic healthy controls, recruited from the out-patient department of
Medicine, BPS Government Medical College for Women, KhanpurKalan, Sonepat, and Haryana. Fasting venous blood
was drawn from each participant for the biochemical analysis of FBS, HbA1C, tMg and iMg. The results are Compared
to controls, the FBS, HbA1C and tMg levels were significantly increased (1.17±0.50 vs. 0.86±0.10 ; p=0.002), whereas
the iMg level was significantly decreased (0.52±0.04 vs. 0.55±0.06; p=0.02) in type 2 diabetic patients. The findings of
significant association in non-diabetic control group(r=0.558, p=0.001) and no significant association between tMg and
iMg in the patient group (r=0.245, p=0.192) strengthens the concept of altered Mg metabolism in diabetes. There were no
significant associations of FBS and HbA1C with tMg and iMg in the diabetic patient group. In conclusion the
observation of decreased physiologically active form of Mg (iMg), despite increased total Mg and loss of correlation
between tMg and iMg, suggests that Mg metabolism in diabetes is significantly altered though without any relation to
glycemic control.