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Scholars Journal of Applied Medical Sciences | Volume-3 | Issue-05
Histomorphometric and Spermatogenic Evaluation of Musk Based-Incense Induced Testisculotoxicity in Adult Albino Rats
Akingbade A.M, Akunna G.G, Faeji C.O, Oyeniran D.A, Adefisayo M.A, Oni O.I
Published: Aug. 30, 2015 |
153
109
DOI: 10.36347/sjams.2015.v03i05.063
Pages: 2111-2117
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Abstract
Male infertility is one of the major health problems in our society and the possibility that chemicals may
disrupt the endocrine system in humans and animals has received considerable attention in the scientific and public
community. This investigation was therefore set up to determine the testiculotoxic effect of musk-based incense (MBI)
on adult albino rats, using histology and sperm parameters. The stereological evaluation of the rat testes showed that the
tubular diameter, the cross sectional area of the tubules, the number of tubular profiles per unit area and the mean
numerical density of seminiferous tubules of the group B rats that were exposed to smoke from 2g of MBI approximated
those of the control animals while rats that were exposed to 3g and 5g of MBI shows a statistically significant (p < 0.05)
reduction when compared. The MBI exposed groups of rats demonstrated reduction of basal seminiferous epithelia cells,
marked testicular atrophy, germinal aplasia and hypo-spermatozoa formation. The results evaluated from the sperm
parameters shows a decrease in sperm motility, a decrease in sperm count, and an increase in abnormal sperm
morphology. Animals in Group B (control) showed a non significant decrease (p > 0.05) in sperm motility, sperm count
and sperm morphology when compared to Group A. Group C & D showed significant decrease (p < 0.05) in sperm
count, sperm motility, and an increase in abnormal sperm morphology. The histological examinations of the MBI
exposed groups of rats showed a derangement of the basal semineferous epithelia, testicular atrophy, germinal aplasia
and hypospermatozoa in the lumen.