DOI: 10.36347/sjams.2015.v03i05.071

Pages: 2146-2152

Majority of fungal Urinary Tract Infections (UTIs) are caused by Candida species. Because of differences in pathogenecity and drug resistance, speciation is desirable. Among the different antifungal agents, resistance to polyene compounds is uncommon while resistance to flucytosine and azoles now appears to be increasing. This study was conducted in the department of Microbiology, Adesh Institute of Medical Sciences & Research from September 2014 to July 2015 during which 100 cases of candiduria were followed. Isolation, speciation and anti fungal susceptibility of Candida spp was performed by standard procedures . 100 Candida spp were isolated from 1857 urine samples, incidence of candiduria being 5.38%. Out of the 100 Candida isolates, C. albicans was commonest 34%, followed by C.dubliniensis (31%), least common was C.glabrata (1%).The common predisposing factors associated with candiduria were intake of antibiotics (99%), followed by IV catheter (95%) Foley’s catheter (90%) and female sex (74%). Out of the 100 Candida isolates, 99% were sensitive to amphotercin B, while sensitivity to ketoconazole was 20%, to fluconazole was 12%, to itraconazole was 9%. All Candida spp were sensitive to amphotercin B except C.krusei whose sensitivity was 94.7%. Sensitivity to itraconazole was maximum by C.Tropicalis (26.6%) followed by C. albicans (8.8%). C.glabrata& C.krusei were most resistant. Sensitivity to ketoconazole was maximum by C.Tropicalis (26%) followed by C. albicans (23.5%). C. Glabrata was most resistant. Sensitivity to fluconazole was maximum by C.Tropicalis (26.6%) followed by C. Albicans (14.7%). C. Glabrata was most resistant.