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Scholars Journal of Applied Medical Sciences | Volume-3 | Issue-06
Peculiarities of the Spectrum of Chromosome Aberrations in the Peripheral Blood Lymphocytes in Cases of Brain Gliomas and their Correction with Verapamil and Ketamine
Gridina N.Ya, Maslov V.P, Kotovsky V.Y, Draguntsova N.G
Published: Sept. 25, 2015 |
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116
Pages: 2156-2160
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Abstract
This work is devoted to question, is the genetic anomalies in glioma cellular genome is asubject to reasons or
consequences of the malignant process? For answer on this question new approach was used, such as comparison of the
genetic abnormalities data between brain gliomas and cerebral brain injury. This two pathologies have different view of
inflammations, and it influence on the genome can investigate by cytogenetic methods. Making into account the
connection between membrane and cell nuclear, pharmacology medications verapamil and ketamine was used for
possible stabilization of nuclear chromosomes. Thus, a disorder of cellular genome in cases of inflammatory processes of
neoplastic and non neoplastic genesis largely is defined with charge properties of cellular membranes and the influence
of channel antagonists (verapamil and ketamine) on cellular membranes promotes the normalization of charge properties
of membranes and stabilization of cellular genome. This result is evidence about such fact, that more of the genetic
aberrations are not reasons, but only consequences of malignant process and it is very important result for utilization in
gene therapy.