DOI: 10.36347/sjams.2015.v03i06.023

Pages: 2273-2276

Increased mortality rate because of Cardiovascular Disease [CVD] is well established in Rheumatoid Arthritis [RA] patients. We have estimated the role of serum malondialdehyde [MDA] and homocysteine levels of serum in RA patients and we correlated whether the biochemical parameters in RA patients are more vulnerable for cardiovascular disease or not. The method in this study Serum MDA and homocystein levels were measured in 28 diagnosed patients of RA in the age from 25 to 65 were compared with healthy controls. MDA was estimated by the method of Randox laboratory. Serum homocysteine was measured by using ELISA kits. The results were Serum MDA levels were higher RA patients than in controls [0.8928 + 1.2168 micromoles/L vs. 0.5688 + 0.4864 micromoles/L; [p<0.05]. There was significant [p<0.05] rise in serum homocsyteine level in patients than in controls [47.25 + 23.109 micromoles/Lvs16.648 + 9.627 micromoles/L]. There was statistical significant [p<0.05] lower hemoglobin than normal & raised ESR levels in the RA patients. Hence we conclude that RA patients had elevated levels of MDA and homocysteine than the control group and both these parameters are common mediator in the pathogenesis of accelerated atherosclerosis.