DOI: 10.36347/sjams.2015.v03i06.034

Pages: 2322-2326

A cross sectional study conducted during the period from May 2013 to December 2015 to assessment the serum levels of malondialdehyde (as a marker of lipid per oxidation), antioxidant vitamins (A, E, C), and zinc in addition to lipid profile in Sudanese with type 2 diabetes mellitus compared to healthy volunteers. Three hundred of diabetic patients who attended ADC centre for routine follow up and a control group of 100 healthy subjects (non-diabetic). Blood specimens were collected from both groups, and plasma levels of Malondialdehyde, antioxidant vitamins (A, E, C), in addition to fasting plasma glucose and glycetaed hemoglobin (HbA1c) were determined. Age and gender of the test group were matched with the control group. The results of the study indicate a significant raised in the means of the plasma levels of malondialdehyde, fasting plasma glucose, cholesterol, LDL, triglyceride, and HbA1c of the test group when compared with healthy control group subjects, whereas the means of the plasma levels of antioxidant vitamins (A, E, C),HDL and zinc showed significant reduction when compared with that of control group In conclusion, the present study indicate that the plasma levels of MDA, antioxidant vitamins (A, E, C) and ,FPG, lipid profile and HbA1c are important markers for evaluation of oxidative stress, antioxidant status, and glycemic control of diabetic patients respectively.