DOI: 10.36347/sjds.2017.v04i05.001

Pages: 211-215

Oxidative stress due to reactive oxygen species (ROS) is one of the etiological factors of periodontal disease. Glutathione peroxidase (GSHPx)has a protective action against ROS and is an established marker of oxidative stress. The present study evaluates the levels of GSHPx in saliva and gingival tissue to further gather information into the role of antioxidants in periodontal disease. A total of 40 subjects participated in the study. The subjects were divided among namely Group A-Total of 20 subjects aged between 30-55 years who have chronic periodontitis. Group B (control) -Total of 20 subjects with healthy periodontium aged between 15-35 years. The values obtained were subjected to students T-test. Saliva and gingival tissue wer collected from all subjects to estimate levels of GSHPx .The results showed that the mean salivary and gingival tissue glutathione peroxidase levels were significantly higher in Group A as compared to Group B subjects. From this study it can be concluded that glutathione peroxidase can be used as a diagnostic marker for periodontal disease.