DOI: 10.36347/sjams.2015.v03i06.046

Pages: 2374-2380

Staphylococcus aureus are increasingly being reported as multidrug resistant with high resistance to macrolides and lincosamides, leaving very few therapeutic options. The aim of the study is to find out the presence of Inducible Clindamycin Resistance among Staphylococcus aureus isolated from various Clinical Samples with special reference to Methicillin Resistant Staphylococcus aureus (MRSA).This is a prospective study and was done in the year 2013 at Govt. general hospital, Vijayawada. Various Clinical samples were collected on random basis to isolate Staphylococcus aureus by observing its characteristics on following standard methods. All erythromycin resistant isolates were processed for Inducible clindamycin resistance by D-test. Out of 164 Staphylococcus aureus isolates in different clinical samples, 119(72.5%) were Erythromycin resistant and 71(43.2%) were found to be MRSA. Among these, 34 (20.7%) were iMLSB (Erythromycin resistant Clindamycin sensitive by D test), 29(17.6%) were cMLSB and 56(34.1%) were MS Phenotype (Erythromycin resistance, Clindamycin sensitive). MRSA isolates were more than MSSA in MS Phenotype. We conclude that it is necessary to perform D-test for detection of inducible clindamycin resistance among Staphylococcus aureus in routine antibiotic sensitivity testing. Therapeutic failures may thus be avoided.