DOI: 10.36347/sjds.2017.v04i10.005

Pages: 434-439

Oral lichen planus (OLP) is a chronic inflammatory disease with unknown etiology which WHO has classified it as a premalignant lesion that could be transformed to oral squamous cell carcinoma (OSCC). Ki67 marker use for identifying divided cells. Therefore, it shows proliferation activity in the normal and tumoral tissues. The aim of this study was to compare the immunohistochemical expression of Ki67 marker in OLP and OSCC. This study was a Laboratory experimental study. Immunohistochemistry (IHC) expression of Ki67 marker was studied in 30 samples of hyperplasia without dysplasia (control group), oral lichen planus and squamous cell carcinoma. The independent T-test was used to compare the expression levels of Ki-67 marker in OSCC, OLP and hyperplasia. Statistical analysis was performed with SPSS Ver.21 software. The mean stained cells in samples hyperplasia were 19.93±7.5%, OLP were 19.4±7.6% and in OSCC were 75.43±13.1%. There was no significant difference in average expression of Ki67 between hyperplasia samples and OLP (P>0.05), but the expression of Ki67 in OSCC was higher than OLP and hyperplasia and this difference was significant (P<0.01). The results showed that Ki67 expression in squamous cell carcinoma was higher than oral lichen planus and hyperplasia and more Ki67 expression in samples of OLP demonstrated an increase in the proliferation and progression to malignancy.