DOI: 10.36347/sjds.2018.v05i01.003

Pages: 17-20

Oral Sub mucous Fibrosis (OSF) is a chronic inflammatory oral potentially malignant disorder caused due to recant chewing characterized by excess collagen deposition in the submucosa leading to restricted mouth opening. Myofibroblasts are the contractile cells expressing α-SMA are seen in tissue repair and wound healing. They are also reported in various fibrotic conditions. The purpose of the study is to evaluate the expression of α-SMA in OSF. 10 normal and 25 OSF tissues are immunohistochemically stained for α-SMA. Majority of the cases in control group showed negative expression for α-SMA. The expression of α-SMA showed significant difference between control and OSF (p=0.00005), control and early OSF (p=0.006), control and advanced OSF (p=0.004). No significant expression was found between early OSF and advanced OSF. Myofibroblasts have a role in OSF. Any intervention that could prevent my fibroblastic differentiation can be therapeutic measure in OSF.