DOI: 10.36347/sajb.2013.v01i04.007

Pages: 136-143

The increasing emergence of several multi-resistant pathogenic microorganisms to synthetic drugs has drawn much attention of researchers to finding new, attractive and natural products such as mushroom species as neutraceuticals because they contain a tremendous variety of secondary metabolites. Hence this work is reported on the influence of metabolites fromSchizophyllum commune wild type and mutants on Escherichia coli induced histopathological changes in Albino rats. S. commune mutant strains were generated by exposing the wild type fungus to ultraviolet rays at various time intervals of 30minutes, 60minutes and 90minutes coded as SCM1, SCM2 and SCM3 respectively. Metabolites from submerged fermentation of the S.commune strains were tested on Albino rats administered with pathogenic E.coli. Histopathological studies carried out on the testes, kidney and liver of the rats showed that SCM2 metabolite performed best in combating the virulence effects of pathogenic E.coli in the testes, kidney and liver tissues of the albino rats as compared to performance of SCM3, SCM1 and SCW respectively, hence SCM2 is recommended for use instead of the wild type in drug production.