DOI: 10.36347/sjams.2015.v03i08.042

Pages: 2948-2953

Metabolic syndrome is a cluster of cardiovascular risk factors. A direct association of normal TSH with insulin sensitivity and abdominal obesity has been shown. The present study designed to assess the prevalence of thyroid dysfunction in patients with metabolic syndrome and its association with components of metabolic syndrome. In this cross-sectional study, the subjects were selected through randomized cluster sampling from the project of Ahvaz metabolic syndrome study included 77 patients with metabolic syndrome and 92 healthy people. Height, weight, waist circumference (WC), BP, and BMI were measured. Blood samples were collected after 12 hours of fasting for FBS, TG, total cholesterol, TSH, T4, T3RU and Anti TPO and Anti TG antibodies and HDL, and people with at least three ATP III criteria were considered as metabolic syndrome. The results in this study included 169 subjects (77 patients with metabolic syndrome in and 92 healthy subjects in control group). In the metabolic syndrome group 55.8% were female and 44.2% were male. There was 48.9% female and 51.1% male in the control group. The prevalence of thyroid dysfunction in patients with metabolic syndrome and normal subjects was 13% and 6.5%, respectively (P=0.24). The prevalence of positive level of thyroid auto antibodies were 48% and 20% in metabolic syndrome patients and control group respectively (P=0.0002). Serum TSH levels had direct and significant association with WC (P=0.01) and BMI (p=0.0001). This study shows that the conclusion was prevalence of thyroid dysfunctions in patients with metabolic syndrome was not significantly higher than normal people, while the prevalence of thyroid auto antibodies was higher in patients with metabolic syndrome. The serum levels of TSH had a significant relationship with some components of the metabolic syndrome, including abdominal obesity and obesity.