DOI: 10.36347/sjams.2015.v03i08.046

Pages: 2980-2984

The incidence of breast cancer (BC) in young women (age < 35) is low. The aim of the present study was to investigate clinico pathological characteristics in young BC patients (35 and less than 35 years old) for the first time in the West of Iran with focusing on recurrence. Between of 2001 to 2008, 79 women with BC referred to our Clinic that all patients had age≤35 years at diagnosis. Age, sex, stage, grade, survival, vascular invasion, perineural invasion, recurrence, tumor markers, lymph node invasion, history of BC, age at first menstruation and age at first pregnancy were checked in the patients. Estrogen receptor (ER) and progesterone receptor (PR) positivity was defined as≥10% positive tumor cells with nuclear staining. Nuclear grade І, ІІ and ІІІ were for 25.3%, 49.4% and 25.3% patients and also 24%, 53.1% and 22.9% for histological grade І, ІІ and ІІІ, respectively. Four patients (5.1%), 50(63.3%), 21(26.7%) and 3(3.9%) had stage І, ІІ, ІІІ and ІV, respectively. Out of 55 patients with lymph node invasion, 35 (63.6%) had 1-3 involvement lymph nodes, 17(30.9%) had 4-10 and 3(5.5%) had >10. Of all patients, 16(20.2%) had recurrence and 22 (27.8%) had history of BC. There was significant correlation between age, stage, metastatic lymph nodes and survival with recurrence (P<0.05). In conclusion, Low age, higher stage and lymph node metastases with four or more positive nodes are prognostic factors for recurrence in young patients with BC.