DOI: 10.36347/sjams.2015.v03i08.057

Pages: 3036-3042

Neonatal mortality is recognized as an important global public health problem, of which more than one-third is due to severe infections and a quarter due to the clinical syndrome of neonatal sepsis. The present study was undertaken to evaluate the risk factors associated with neonatal sepsis and formulate a proper guideline for management on analysis of the antimicrobial susceptibility patternin this geographical area of North East India. On clinical suspicion of septicaemia, at least two sets of test for blood culture were performed. The data obtained of culture proven septicaemia were analysed in reference to onset and associated risk factors. Sepsis was suspected in 150 cases and blood culture was positive in 59(39.3%) cases. Early Onset Septicaemia (EOS) was confirmed in 34 neonates (57.6%) and Late Onset Septicaemia (LOS) in 25 patients (42.4%). The most important maternal and neonatal risk factor found associated with the proven cases of septicaemiawere maternal pyrexia (16.9%) and Low Birth Weight (71.2%) respectively. Septicaemia was more associated with Operative delivery (64.4%). Among the clinical features, Pneumonia was found in 55.9% neonates followed by respiratory distress and tachypnea. Staphylococcus aureus was the most predominant blood culture isolate (32.2%) followed by Klebsiella pneumoniae (22%).All the gram positive blood culture isolates were sensitive to Vancomycin. The Cephalosporins, Clindamycin and Amikacin were found significantly sensitive in Staphylococcus aureus(94.7%). All gram negative isolates were sensitive to Imipenem, followed by Piperacillin-tazobactum and Amikacin. The first line regimen for treatment of cases of septicaemia in our setting was chosen to be Amikacin along with a third generation Cephalosporin like Cefotaxime.