DOI: 10.36347/sajb.2014.v02i07.010

Pages: 448-453

The objective of this study is to determine, the effects of falciparum malaria parasites on pancreatic secretions specifically the serum α–amylase and insulin concentration. The study was conducted in Gezira state, Eastern Locality (Rufa’a), during September 2011 to March 2012, when transmission reaches the peak. 104 patients of well defined malaria case participated as a study group and 40 apparently healthy volunteers participated as a control group from both sex and their ages vary from 10 to 60 years old. Venous blood sample was taken from each individual before and after anti-malarial therapy and analyzed for α-amylase activity by using colorimetric method, and insulin hormone level by using Immunochemilumino-metric assay. 35 out of 104 (33.7%) of the enrolled patients shows high level of serum α–amylase, while the remainder 69 (66.3%) have normal α-amylase, (23.3%) subjects suffering from abdominal pain. Results obtained when comparing, serum α-amylase level of the study group with the control group it shows significant difference (P. value 0.002). The α-amylase level is significantly increased in patients with malaria, when it compared with its level after complete recovery (P. value 0.000). The α-amylase level in patients with malaria suffering from abdominal pain, shows a significant difference when it compared with those without abdominal pain (p.value0.04). When comparing the α-amylase level with malaria parasite density groups (scanty, moderate, high, very high) it shows insignificant differences P. values (0.52, 0.23, 0.46, 0.07, 0.76, 0.10) respectively. From a total of 104 patients 65(62.5%) with normal insulin level, while the remainder 31 patients (29.8%) with low insulin level, the other 8 patients (7.7%) show’s elevated insulin. Results obtained when comparing serum insulin level of the study group with the control group it shows significant difference (P. value 0.027). The insulin level when it compared between before treatment and after co