DOI: 10.36347/sjams.2015.v03i09.014

Pages: 3203-3210

Laryngoscopy and endotracheal intubation are strong noxious stimuli which cause sympathetic stimulation leading to marked increase in release of catecholamine. There occurs increase in heart rate and blood pressure within 5 seconds of the procedure, peak effect observed in 1 to 2 minutes and returns to baseline with in 5 to 10 minutes. In this context, the present study was undertaken, to compare two doses of Dexemedetomidine in attenuating the hemodynamic response, observe the level of sedation and any untoward effect. 90 patients aged 30 to 50years, were divided into two groups of 45each. Before induction of anaesthesia both the groups received Dexemedetomidine 0.5 mcg/kg and 1.0 mcg/kg body weight respectively in 10 ml of normal saline over a period of 10 minutes. Patients were observed for 5 minutes during which sedation level was recorded at 3rd& 5th minute. Heart rate, Systolic blood pressure, Diastolic blood pressure, Mean arterial pressure, Rate pressure product were recorded at different times like before administration of test drug, 5 minutes after injecting the test drugs, immediately after intubation and at 1, 3, 5,8,10 minutes. Data obtained were statistically analyzed& compared. There was significant decrease in all observed hemodynamic parameters in both groups at different times from baseline, However patients receiving Dexemedetomidine higher dose (1.0mcg/kg) the change was more significant compared to the other Group. Therefore it can be concluded that, Dexemedetomidine prior to induction of anaesthesia attenuates the cardiovascular response to laryngoscopy & intubation in a dose dependent manner.