DOI: 10.36347/sjams.2015.v03i09.033

Pages: 3316-3320

Diabetes Mellitus (DM) is a chronic metabolic disease causing disorders in carbohydrate, protein and fat metabolism, which occurs as a result of deficiency in the secretion and effect of the insulin hormone. Pancreatic islet cell differentiation and basic helix-loop-helix transcription factor for regeneration neurogenin-3 (Ngn-3) has a critical role. The results obtained with type 2 diabetes susceptibility to the disease, the efficacy of treatment in type 2 diabetics and are intended for receipt of these measures. In this study, the susceptibility to Ngn-3 gene polymorphisms and expression with type 2 diabetes disease has investigated the relationship between treatment and control activities. The materials and methods in this study, Firat University Scientific Research Projects Coordination Unit and ethical approval of the study was performed according to the decision of 11.10.2012 date and No. 01 The present study included volunteered 40 patients who live around Elazığ Province, who were diagnosed with Type 2 DM and who are aged over 30 years (10 male and 10 female who received only oral anti-diabetic treatment and 10 male and 10 female who received no medication) and volunteered 40 individuals in control group (20 male and 20 female) who are aged over 30 years. In addition to routine blood examinations, Neurogenin-3 (Ngn-3) gene polymorphism and gene expression were examined in the study groups. In results the study compared Type 2 DM (n=40) and control (n=40) groups in terms of Ngn-3 rs4536103 gene area polymorphisms. There was no significant difference between these two groups in terms of Ngn-3 area gene polymorphisms rates (p=0,597). Significant correlation was detected between SNP rs4536103of the Ngn-3 expression, polymorphism and BMI (p= 0.04).