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Scholars Journal of Applied Medical Sciences | Volume-4 | Issue-01
Polycaprolactone and polycaprolactone/ chitosan electrospun scaffolds for tissue engineering applications
Alexandros Repanas, Lothar Lauterboeck, Dimosthenis Mavrilas, Birgit Glasmacher
Published: Jan. 30, 2016 |
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DOI: 10.36347/sjams.2016.v04i01.043
Pages: 228-232
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Abstract
Scaffold engineering and fabrication techniques play a fundamental role in biomedical engineering
applications. Tissue engineering has been considered as a very promising alternative therapeutic strategy compared to
traditional approaches in order to reduce the cost of treatment for patients and cope with the need for finding suitable
donors for transplantations and tissue/ organs regeneration. Several novel approaches have been employed, including the
production of biological, synthetic and bio-artificial hybrid formulations that can mimic the structural, physicochemical,
mechanical and biological properties of natural tissues and organs. Electrospinning, which belongs to the electro
hydrodynamic techniques, has been considered as a suitable technology to fabricate non-woven fibrous formulations that
could be utilized as scaffolds. In the present study, blend electrospun fibers made of polycaprolactone (PCL) and
chitosan (CS), using trifluoroethanol (TFE) as an alternative solvent; have been investigated regarding their structural,
physical and mechanical properties. Different scaffolds characteristics, such as average fiber diameter, porosity, density,
contact angle, hydration and mechanical properties have been studied, and a comparison between PCL and PCL/ CS
fibers was performed. In a nutshell, PCL/ CS fibers were thinner, more hydrophilic, exhibiting higher porosity and
superior mechanical properties, compared to PCL fibers, and therefore could be considered as suitable scaffolds for tissue
engineering applications.