DOI: 10.36347/sjds.2019.v06i05.002

Pages: 257-259

Background: To better simulate and tap the potential clinical application of Chlorhexidine, it seems necessary to evaluate the concentration of Chlorhexidine, which can be clinically used in dental practice. Aim: To assess the substantivity of of different medicaments in chlorhexidine-treated human root dentin. Methods: This prospective study was conducted on forty five patients. They were divided into three groups. Group I specimens were then treated with 10 microliters of 0.02% Chlorhexidine, Group II specimens with 10 microliters of 0.2% Chlorhexidine, and Group III specimens were treated with 10 microliters of 2% Chlorhexidine. They were then incubated in 1 ml of Phosphate buffer ed saline. The substantivity was evaluated after 24 hours and one week of incubation. Results: Highest substantivity was seen for Group II at 24 hours (84%) as compared to at one week (83.9%). Substantivity in Group I was a little lower than that seen in Group II. Substantivity was seen for Group I at 24 hours (83.1%) as compared to at one week (82.8%). Highest substantivity was observed for Group II then Group I, as compared to Group C; with both groups performing significantly better than Group C. Conclusion: On the basis of findings of this study, it can be stated that 0.02% and 0.2% Chlorhexidine can be used in dental practice to enhance the stability of a dentin-adhesive interface. Further larger controlled trials are warranted to support our findings.