DOI: 10.36347/sjds.2019.v06i07.006

Pages: 352-355

Objective: The aim of this study was to evaluate and compare the biological effects of seven composite resins (Clearfil Majesty ES-2, Clearfil Majesty ES Flow, Grengloo, Blugloo, Transbond XT, Transbond LR and Filtek Supreme XTE) on human gingival fibroblasts. Methods: Human gingival fibroblasts were cultured up to confluence. Cultures were exposed to composite resins for 24 hours and cell viability measured by MTT assay. Results: All composite resins showed reduced values (85 to 94%) of cell viability compared to the control. Conclusions: Orthodontic and dental composite resins are toxic to human gingival fibroblasts. Dental materials that are used in dentistry should be harmless to oral tissues, so they should not contain any leachable toxic and diffusible substances that can cause some side effects.