DOI: 10.36347/sjds.2019.v06i08.004

Pages: 373-379

Context: Medicinal plants signify a rich source of antimicrobial agents. Plants are used medicinally in many countries and are sources of various potent and prevailing drugs. Carica papaya is a known medicinal plant in that it comprises constituents that can be used for therapeutic purposes. Aim: To assess antimicrobial potential of different concentrations of ethanolic papaya leaf extract against Candida albicans (C albicans) and Enterococcus faecalis (E faecalis).Settings and Design: Laboratory setting and Experimental design. Methods and Material: In first part of study, 10%, 20% and 30% ethanolic papaya leaf extract was prepared in the laboratory of Pharmacy College. 10%, 20% and 30% ethanolic papaya leaf extract was then subjected to microbiological assay to determine its zone of inhibition using Agar disk diffusion test and Minimum Inhibitory concentration (MIC) using Serial broth dilution method against C albicans, and E faecalis. Results: 10%, 20% and 30% ethanolic papaya leaf extract showed: a) Maximum zone of inhibition of 10 mm, 12 mm and 14 mm respectively against C albicans b) Maximum zone of inhibition of 11mm , 12 mm and 15 mm respectively against E faecalis. b) MIC of 2.5% and 1.25% agains, Candida albicans and Enterococcus faecalis respectively. Conclusion: Different concentrations of ethanolic papaya leaf extract possess antimicrobial potential against both pathogens used in the study.