DOI: 10.36347/sjams.2016.v04i02.047

Pages: 553-556

Cancers in the proximal colon, distal colon, and rectum are frequently studied together; however, there are biological differences in cancers across these sites, particularly in the prevalence of microsatellite instability. The aim of the study is to evaluate prognostic factors and survival in CRC patients based on tumor site in Northeastern Iran. Between of 2010 to 2015, 94 patients with CRC referred to Oncology Clinic in Mashhad city, Iran. The patients were divided on two groups based on tumor site (37 patients in colon group and 57 patients in rectum group). The mean follow-up was 30 months. In this interval, there were 19 deaths and 7 patients lost follow-up and therefore, were censored from survival analysis. In results the mean age at diagnosis of colon group was 58.8 years (range, 23-89 years) versus 56.5 years (range, 28-85 years) for rectum group. Mucinous adenocarcinoma was more in colon group compared to rectum group (P<0.05). Survival rate and mean for colon group was 79.4% and 17.7 months, respectively, versus 75% and 22.5 months for rectum group, respectively (P>0.05). In conclusion the prevalence of rectal cancer in Iran is higher than other studies compared to colon cancer. Also, the mean age of rectal cancer patients were less than colon cancer patients and in all studies; there was no significant difference in survival in two groups.