DOI: 10.36347/sjams.2016.v04i02.055

Pages: 601-605

The clinical and biochemical profile of type 2 diabetic patients is entirely different in Indian population as compared to western population. 97 patients of type 2 DM were subdivided into obese, nonobese and lean groups and their clinical and biochemical parameters were studied. About 20% of patients were lean (BMI < 19). The mean age of type 2 DM was 51yrs. The WHR was also not statistically different in three groups implying greater prevalence of central adiposity in Indian population. The lean diabetic patients had higher fasting (192mg/dl), postprandial glucose (277mg/dl) and mean HBA1C (9.03%) values as well as significantly higher triglyceride levels (229mg/dl) suggesting possibility of both greater endogenous insulin deficiency and insulin resistance. However, the obese diabetics had higher LDL (142mg/dl) which is reflected by the greater incidence of ischemic heart disease (25%) and stroke (7%) in this subgroup. The findings regarding microvascular events were converse, the lean patients had microalbuminuria (42.85%), nonproliferative retinopathy (29%), proliferative retinopathy (14%) gloves and stocking anaesthesia (43%) and absent ankle jerk (19%) which were significantly higher than other two subgroups. The study shows that lean diabetic patients are at higher risk of metabolic derangements and microvascular complications and thus need aggressive management.