DOI: 10.36347/sjams.2016.v04i03.021

Pages: 732-735

Albino rats were chosen for the present study and the total animals were divided into eight groups (S1 -S8), each consisting of six animals in it. The control animals (S1) were fed with conductivity water while the experimental animals were fed with the single dosage of Sildenafil citrate (Caverta). S2, S3, S4 and S5 group of animals were sacrificed respectively after 1hour, 2.5 hours, 4 hours and 24 hours of drug administration. S6, S7 and S8 group of animals were fed with the single dose of the said drug daily for 15, 30 and 45 days respectively and then, sacrificed after 4 hours of the last dosage of the drug. The kidney samples of the control and experimental animals were subjected to light microscopic analysis. From the present study, it has been found that the long-term Caverta treatment resulted in a considerable increase in periglomeruli space, destruction of glomeruli, increase in the number of vacuolated cells and the destruction of the normal architecture of the kidney. The outcome of the present study clearly depicts the fact that Sildenafil citrate (Caverta), if administrated on long-term basis, will produce adverse effects on the structure and vital function of the kidney of Albino rats.