DOI: 10.36347/sjams.2016.v04i03.043

Pages: 836-841

Multi-drug and extensively drug resistant tuberculosis (M/XDR-TB) has been an area of growing concern among clinicians, epidemiologists, and public health workers worldwide. This study was conducted with objective to assess the clinical, radiological, conversion rate as well as the association with each other in Multi-Drug Resistant Tuberculosis (MDR-TB). This hospital based analytical type of observational study was conducted in the department of Respiratory Medicine, JLN Medical College Ajmer, on the 244 Multidrug Resistant Pulmonary Tuberculosis patients at PMDT site were included who were consecutively enrolled for category IV regimen during period, 1st January to 30th September 2012 . They (N=103) were followed up for 24 months clinically, and bacteriological by sputum smear, culture and Drug Susceptibility Testing (DST) at regular intervals. The data were analyzed by chi square test. Out of 244 patients, 74.6% patients were in the reproductive and economically productive age group of 16 - 45 years. According to radiological outcome, 66.9% evidence of radiological improvement, whereas 24 (23.3%) patients had radiological deterioration, while in 10 (9.7%) patients radiological picture was stationary. statistically highly significant association between clinical symptoms, radiological and conversion among follow up patients was observed(p value < 0.001). Sputum smear and culture conversion are very well associated with clinical and radiological improvement. Category IV regimen of DOTS-Plus under RNTCP program in MDR-TB patients produced significant improvement in body weight, bacteriological, and radiological examination.