DOI: 10.36347/sjams.2016.v04i03.050

Pages: 877-886

Diabetes mellitus (DM) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia. Macro- and microvascular disease are currently the principal causes of morbidity and mortality in patients with type 1 and type 2 DM. DM has been recognized as a „prothrombotic tendency‟ with increased platelet reactivity. This enhanced reactivity has been postulated to play a role in the microvascular complications of diabetes. The study was aimed at analysis of platelet indices -MPV and PDW and its relation with endothelial dysfunction in patients of DM. This study included 100 subjects, 50 diabetics and 50 healthy subjects from the hospital as controls. Anticoagulated blood was collected and analyzed in an automated blood cell counter for platelet count, Mean platelet volume (MPV) and platelet distribution width (PDW). Endothelial dysfunction was assessed indirectly by vessel reactivity using non-invasive automated digital thermal biofeedback mechanism. In results we studied 50 healthy (mean age 56.56±11.06 years) and 50 diabetics (mean age 56.8±7.96). MPV 8.96±1.93 fL was significantly higher and PDW 19.11±1.45 10(GSD) was raised in diabetic patients compared to the controls (MPV 7.57±2.54 fL and PDW 18.93±1.07 10(GSD). Post cuff deflation temperature rebound (TR) was significantly lower in patients with DM type 2 as compared to normal subjects indirectly reflecting endothelial dysfunction. The diabetic subjects were unable to achieve the basal temperature even after 2 minutes of cuff deflation as compared to controls where temperature rebound was achieved within 1 minute. This difference was statistically significant (P = <0.005). In conclusion the Platelet indices; MPV was significantly raised where as PDW was higher in diabetics and this was directly related to delay in temperature rebound reflecting endothelial dysfunction.