DOI: 10.36347/sjams.2016.v04i04.004

Pages: 1116-1118

Gallstones are the major cause of corbidity worldwide, Gallstones (cholelithiasis) develops because of an imbalance in the chemical composition of bile inside the gallbladder and it is due to multifactorial etiology which includes chronic alcoholism. Patients undergoing (cholecystectomy) once symptoms appear. The important complications of long term gallstones are acute pancreatitis, cholecystitis, obstructive jaundice which alter the liver function and decrease the life expectancy. The main aim in the present study was conducted to assess the Biochemical variations in gallstone diseases among alcoholics in coastal region of karaikal. The Materials and methods were A total of 22 patients(case) in which 11 alcoholics and 11 non alcoholics who were age and sex matched with multiple stones in gall bladder, symptomatic and undergoing cholecystectomy were recruited for this study . 25 normal individuals as controls were recruited for this study. Serum total and direct bilirubin were estimated by DMSO method. Serum SGPT, SGOT, GGT, Lipase, Amylase and Serum alkaline phosphates level were estimated. The Results In the present study liver function biochemical parameters were found to increase in alcoholic gallstone disease individuals when compared to healthy individuals and also compared to gallstone disease nonalcoholic subjects. ALP and Direct bilirubin were significantly elevated in alchoholic gallstone disease subjects (p=0.01, p=0.04) when compared to healthy individuals. Finally the Conclusion thus elevated biochemical parameter levels in blood could predict the presence of liver damage and also indicates the severity of gallstone disease and its complications among alcoholics in coastal region.