DOI: 10.36347/sjams.2022.v10i11.018

Pages: 1914-1917

Background: Early pregnancy failure is a major public health problem throughout the world. It has been estimated that over 10-20% of pregnancies end up in spontaneous abortion and 80% of all these occur before 12 weeks. Mifepristone and Misoprostol are drugs, which are easy to store and require no surgical skills to administer, providing an alternative to surgical intervention that could increase access to abortion care. Objective: The objective of the study was to evaluate the safety, effectiveness, and acceptability of oral mifepristone and misoprostol for the termination of first- trimester pregnancy. The study was carried out in the department of Obstetrics and Gynecology, Holy Family Red Crescent Medical College Hospital, Dhaka, conducted from June 2021 to May 2022. Methods: A total of 80 women participants of reproductive age group with miscarriage at gestational age up to 28 weeks attended the outdoor of Holy Family Red Crescent Medical College Hospital, Dhaka. A complete history was taken from each patients and accompanying attendants. A thorough clinical examination was done. Relevant investigation reports were collected. Patients were given a tablet of Misoprostol on day 1. Mifepristone & Misoprostol, in the divided dose and repeated after 2 weeks & after 2 weeks only misoprostol is given for 3 days as per needed. They were followed up for 1-3 days before discharge. Participants were asked to return to the hospital two weeks later to conform to clinical status. If incomplete termination was determined by clinical exam or by ultrasound in either of the study arm, women were given the option for surgical evacuation or 500 mcg of Misoprostol for additional follow-up 1 week later to see if expulsion would have occurred spontaneously. If, after the second follow-up visit, abortion was not complete, a surgical completion was performed. Results: Patients belonged to the age group 18-25 years. Maximum numbers of cases were multiparous and belonged to 7-8 .........