DOI: 10.36347/sjams.2016.v04i04.044

Pages: 1334-1337

Chronic idiopathic urticaria (CIU) is common but one of most frustrating therapeutic problem faced by the dermatologists. About 30% of CIU patients have histamine releasing the auto-antibodies in their blood. The term autoimmune urticaria is increasingly being accepted for this subgroup of patients. The autologous serum skin test (ASST), which indicates the presence of functional circulating auto antibodies to FcƐRIα &/ to IgE, is the best invivo test for detection of basophil releasing histamine activity in vitro. Few studies reported that autologous plasma skin test (APST) is positive in more patients of chronic urticaria than ASST. This study aims to find the prevalence of the APST positive cases among Indian patients with CIU. The autologous plasma skin test were done in all patients with chronic urticaria of more than six weeks duration. Physical urticaria, urticarial vasculitis, pregnant & children <12 years patients were not included in the study. Out of the 30 patients examined, 14 patients (46.66%) had positive APST and 16 patients (53.33%) had negative APST with negative controls. Prevalence 46.66% positivity correlates with previous studies. The APST also a simple, less time consuming tool to measure the auto reactivity of the skin like ASST.