DOI: 10.36347/sjams.2016.v04i04.050

Pages: 1375-1378

Schistosomiasis is the third most devastating tropical disease in the world (200,000 deaths annually). A protective granulomatous response is initiated by the arrival of eggs in the liver. The response results in chronic liver fibrosis as the infection progresses. This complication has an impact on the liver function. The aim of the study was to evaluate the effect of Schistosoma Mansoni on the plasma protein patterns. The study was conducted on 32 adult’s patients with Schistosoma Mansoni and 41 adults’ healthy individuals at New Half a (Sudan) during the period from 2008 to 2010. Serum protein was analysed by electrophoresis and photometric method. The mean values in g/dL± SD of the different protein patterns in the patients group are as follows: Total proteins: (7.19 g/dL ± 0.80 ), albumin: (3.29 g/dl ± 0.61 ), α-1: (0.43 g/dl ± 0.22 ), α-2: (1.37 g/dl ± 0.43 ), β-1: (1.12 g/dl ± 0.68), β-2: (0.58 g/dl ± 0.21 ), and γ: (0.87 g/dl ± 0.50). The mean values in g/dL± SD of the different patterns in the control group are as follows; Total proteins: (7.29 g/dl ± 0.61), albumin: (4.01 g/dl ± 0.54). α-1: (0.27 g/dl ± 0.12), α-2: (1.26 g/dl ± 0.46), β-1: (0.94 g/dl ± 1.02), β-2: (0.57 g/dl ± 0.18), and γ- globulins: (0.84 g/dl ± 0.18). The results showed that there was a significant decrease in albumin and an increase in α-1 globulins in patients group when compared to the control group. There were no differences in the remaining patterens. The study concluded that schistosoma mansoni infection may be one of the causes of low plasma albumin and increased alpha-1 globulin in Sudan. The Hypoalbuminemia may be attributed to decreased synthesis due to less albumin mRNA in hepatocytes or attributed to malabsorption due to damaged intestinal mucosa resulting from the extrusion of large numbers of eggs.