DOI: 10.36347/sjams.2016.v04i05.080

Pages: 1833-1836

Neonatal sepsis is a serious condition resulting from the effects of severe bacterial infection in the first month of life. The clinical diagnosis of neonatal sepsis is difficult due to nonspecific signs and symptoms. The objective isto evaluate the role of different indirect markers in the early diagnosis of neonatal septicaemia. A Prospective cross sectional study had been done in Kalinga Institute of Medical science, Bhubaneswar, India. Blood was collected for estimation of indirect sepsis markers like, Total platelet count, Total leukocyte count , C-reactive protein(CRP), Immature to total neutrophil ratio(I:T) & micro-ESR & culture sensitivity. Sensitivity, specificity positive predictive value of different test was done. Sensitivity of two tests combination was better than the individual test. CRP+I: T ratio was most sensitive & specific parameter. Three test combinations have no added advantage than two test combination. It was concluded that even if two Indirect Sepsis Markers are positive the neonates should be presumed to have probable sepsis and early intervention should be started immediately to prevent the morbidity and mortality of neonatal sepsis.