DOI: 10.36347/sajb.2018.v06i01.002

Pages: 5-13

Dyslipidemia is one of the major modifiable risk factor. Low density lipoprotein cholesterol (LDL-C) acts as the primary lipid agent for CAD risk prediction and therapeutic target, emphasizing the importance of accuracy and precision of LDL-C estimation. The aim of this study is to compare the results obtained by direct homogenous assay for LDL-C to those obtained by Friedewald’s formula and Anandraja’s formula in north Indian population catered to our Hospital and their correlation. Lipid profile reports of 500 patients above 18 years (TG<400mg/dl) were anlaysed. LDL-C estimation was done by homogenous assay and also calculated using the Friedewald’s Formula and Anandaraja’s Formula along with their correlation studies. According to Friedwald formula and Anandraja’s formula 9.8% and 6.4% patients were classified under low risk category respectively but showed a significant positive correlation of 0.95 and 0.91 between direct LDL and FFLDL and AFLDL. Calculated LDL-C results obtained by Friedewald’s and Anandaraja’s formulas show very good correlation with the measured LDL-C but underestimate risk of heart disease when compared to direct LDL cholesterol. LDL-C is considered as the primary basis for diagnosis, treatment and risk classification of patients with hyperlipidemia and it is imperative to validate all these formulas normal healthy and diseased in large populations for a definitive concluding remark