DOI: 10.36347/sajb.2018.v06i01.009

Pages: 65-70

Hypertension is the most common of the cardio vascular diseases which is the leading cause of morbidity and mortality in the industrial world as well as becoming a modern epidemic in the developing countries Hypertension (HTN) is a major modifiable risk factor for Cardio Vascular Disease. Also HTN produces imbalance between pro oxidants and antioxidants leading to increased oxidative stress, in turn leads to Atherosclerosis and Dyslipidemia. Incidence of HTN has been increasing in India between 3rd and 6th decades of life. 90-95% of the HTN falls under the primary or essential or idiopathic type and the cause is unknown it is suggested that the pathophysiology might result from the interactions between genetic and the environmental factors. For the said purpose, a study of 80 hypertensive subjects and 51 non hypertensive and healthy subjects was carried out. Blood investigations in terms of Sugar, Urea, Creatinine, Lipid Profile and Uric Acid were estimated by standard kit method. Oxidative stress parameters (i.e) Plasma Malon di aldhyde (MDA) were estimated manually by Ester Bauer and SteinBerg method. Anti-oxidant parameters (i.e) Plasma vitamin C was estimated manually by Roe and Kuether method. Hypertension is the most common of the cardio vascular diseases which is the leading cause of morbidity and mortality in the industrial world as well as becoming a modern epidemic in the developing countries. Blood pressure (BP) is a powerful cardiovascular (CV) risk factor that acts on the arterial wall5. So, the aim of this study is to assess the level of oxidative stress parameters, with antioxidants parameter vitamin C and correlating the results with hypertension by analyzing selected samples through suitable methods It is proven from the study that the oxidative stress parameters are at a higher level and the antioxidant parameters are at a lower level. It is also suggested that the anti-oxidant supplementation may enhance the scavenging of free radicals and prevent