DOI: 10.36347/sajb.2018.v06i03.007

Pages: 273-278

Enzymes of Ten-Eleven Translocation family belong to the superfamily of Fe2+- and 2-oxoglutarate (2OG)-dependent dioxygenases. TET proteins are known to have important regulatory roles. Early studies of DNA methylation patterns TET proteins and their role in regulation of DNA methylation/de-methylation patterns. Till now a day no molecule of TET3 protein in case of human is available in PDB. Protein Data Bank contains crystal structure of TET1 and TET2 protein but no one molecule of TET3 available in case of Homo sapiens. Formations of 3D structure of TET3 protein in case of human with I-TASER software, it is a first crystal structure of TET3 protein in case of human. Prospect crystal structure of protein validate with X-Ray Crystallography and used too many computational and bioinformatics approaches.